Thermo Fisher Scientific GEMIN8 Polyclonal Antibody
Thermo Fisher Scientific의 GEMIN8 폴리클로날 항체는 인간 GEMIN8 단백질(aa 1-242)에 특이적으로 반응합니다. Western blot과 ELISA에 적합하며, 친화 크로마토그래피로 정제된 액상 항체입니다. 세포질 및 핵에서 GEMIN8 검출에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–242 of human GEMIN8 (NP_0603261) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.52 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805531 |
Product Specific Information
Immunogen sequence:
MAAVKASTSK ATRPWYSHPV YARYWQHYHQ AMAWMQSHHN AYRKAVESCF NLPWYLPSAL LPQSSYDNEA AYPQSFYDHH VAWQDYPCSS SHFRRSGQHP RYSSRIQAST KEDQALSKEE EMETESDAEV ECDLSNMEIT EELRQYFAET ERHREERRRQ QQLDAERLDS YVNADHDLYC NTRRSVEAPT ERPGERRQAE MKRLYGDSAA KIQAMEAAVQ LSFDKHCDRK QPKYWPVIPL KF
Positive Samples: A-549, HT-29, HepG2
Cellular Location: Cytoplasm, Nucleus, gem
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. It is essential for splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA. In the cytosol, Sm proteins are trapped in an inactive 6S pICln-Sm complex by CLNS1A, which controls core snRNP assembly. The SMN complex releases CLNS1A and facilitates transfer of Sm proteins to the SMN-Sm complex, triggering snRNP assembly and nuclear transport.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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