Thermo Fisher Scientific CABP7 Polyclonal Antibody
CABP7 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, Western blot, IHC, ELISA에 적합합니다. 인간, 생쥐, 랫드 시료에 반응하며, 액상 형태로 제공됩니다. 골지체 및 세포막 단백질 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 100–180 of human CABP7 (NP_8723331) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805529 |
Product Specific Information
- Immunogen sequence: PKLSTSGIPE KFHGTDFDTV FWKCDMQKLT VDELKRLLYD TFCEHLSMKD IENIIMTEEE SHLGTAEECP VDVETCSNQQ I
- Positive Samples: Mouse brain, Mouse lung, Mouse kidney, Rat lung, Rat kidney
- Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Single-pass type IV membrane protein, perinuclear region, trans-Golgi network membrane
Target Information
Calcium binding proteins (CaBP) play a crucial role in calcium-mediated cellular signal transduction in the central nervous system. The CaBP family shares similarity with calmodulin (CaM I), and CaBP proteins can substitute or augment CaM I function.
CaBP7 (Calcium-binding protein 7) contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.
CaBP7 and CaBP8 possess a unique targeting mechanism among CaBPs, contributing to differential Ca²⁺-sensing functions.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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