Thermo Fisher Scientific HGS Polyclonal Antibody
HGS 단백질을 표적하는 Thermo Fisher Scientific의 goat polyclonal antibody로, Western blot 및 IHC(P)에서 사용 가능. 인간 반응성, 비접합형, 0.5 mg/mL 농도, TBS 기반 저장. 연구용으로 세포 신호전달 및 단백질 분류 연구에 적합.
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (Paraffin) (IHC (P))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (NRNYWEKKQEEARK) corresponding to internal amino acids of HGS (aa 331–345) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981532 |
Product Specific Information
- Predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It may act as a direct effector of PI3-kinase in the vesicular pathway via early endosomes and regulate trafficking to early and late endosomes by recruiting clathrin.
HGS may concentrate ubiquitinated receptors within clathrin-coated regions and is involved in down-regulation of receptor tyrosine kinase via multivesicular bodies (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to lysosomal sorting/trafficking processes.
HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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