Thermo Fisher Scientific HSD3B1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody has been tested in Peptide ELISA with an antibody detection limit dilution of 1:128,000.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE). The remnant protein is further processed by gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, producing the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores and neuritic plaques, also found in neurofibrillary tangles. Beta amyloid deposits are characteristic of Alzheimer’s disease and are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.