Thermo Fisher Scientific mGluR2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human mGluR2, validated for IHC (Paraffin). Detects metabotropic glutamate receptor 2 involved in excitatory neurotransmission. Supplied as liquid, unconjugated form at 1 mg/mL. Suitable for research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 32 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminal extracellular domain of human mGluR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560070 |
Product Specific Information
PA1-23573 detects Metabotropic Glutamate Receptor 2 in Human samples.
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. For many years it was considered to act only on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors that mediate fast excitatory synaptic transmission.
Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins, known as metabotropic glutamate receptors.
- Group-I receptors stimulate phospholipase C, increasing phosphoinositide turnover and calcium release from internal stores.
- Group-II and Group-III receptors inhibit adenylyl cyclase.
- Group-I receptors include mGluR1a and mGluR5.
- Group-II receptors include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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