Thermo Fisher Scientific alpha-2c Adrenergic Receptor Polyclonal Antibody
Rabbit polyclonal antibody against human alpha-2c Adrenergic Receptor. Validated for IHC (Paraffin). High specificity and affinity purified. Supplied as liquid in PBS with sodium azide. Suitable for neuroscience and receptor signaling research.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 26 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide, KLH conjugated, corresponding to the N-terminal extracellular domain of human alpha-2c Adrenergic Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557579 |
Product Specific Information
PA1-23562 detects alpha-2c Adrenergic Receptor in human samples.
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily, including three subtypes: alpha2A, alpha2B, and alpha2C. These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system. Studies in mice indicate that both alpha2A and alpha2C subtypes are essential for normal presynaptic control of transmitter release in the heart and central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, while the alpha2C subtype modulates neurotransmission at lower nerve activity levels. This gene encodes the alpha2C subtype, which lacks introns in both coding and untranslated regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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