Thermo Fisher Scientific alpha-1b Adrenergic Receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human alpha-1b Adrenergic Receptor. Validated for IHC (paraffin) at 11 µg/mL. Supplied unconjugated in liquid form (1 mg/mL). Suitable for research use in studies of vascular tone, blood pressure, and receptor signa...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 11 µg/mL |
Product Specifications
| Category | Specification |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from C-terminus of human alpha-1b Adrenergic Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2305353 |
Product Specific Information
PA1-23575 detects Alpha 1b Adrenergic Receptor in human samples.
Target Information
The alpha-1b adrenoceptor is an adrenergic receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and contributes to the development of atherosclerosis.
Decreased alpha-1b adrenoceptor expression is associated with benign prostatic hyperplasia (BPH).
This receptor can act as a proto-oncogene when transfected into cell lines, where constitutive activation induces neoplastic transformation.
The alpha-1b adrenoceptor is documented in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen.
ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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