Thermo Fisher Scientific Pax2 Polyclonal Antibody
Pax2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 인체 및 설치류 등 여러 종에 반응하며, 친화 크로마토그래피로 정제된 액상 항체. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 255–305 on human PAX2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Pax genes are a family of transcription factors active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box, enabling them to control genetic programs. Several Pax genes are associated with developmental mutations such as:
- Pax-3: Waardenburg syndrome
- Pax-6: Aniridia
- Pax-2: Wilms tumor
During embryogenesis, Pax-2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures derived from mesenchyme. Pax-2 mRNA and protein levels decrease as the tubular epithelium matures. However, Pax-2 expression persists in the undifferentiated epithelium of Wilms tumors, correlating with proliferation of poorly differentiated epithelial cells. Expression of the Wilms tumor suppressor protein WT1 coincides with down-regulation of Pax-2, suggesting WT1 directly represses Pax-2 transcription.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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