Thermo Fisher Scientific Spectrin beta-3 Recombinant Superclonal Antibody (11HCLC)

Applications

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, and Rat.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies to provide the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

Functionally similar to polyclonal antibodies—recognizing multiple epitope sites and providing higher detection sensitivity for low-abundance targets—these antibodies have a defined mixture of light and heavy chains that ensure reproducibility across production lots.

Note: Formerly called “Recombinant polyclonal antibody,” this product is now branded as “Recombinant Superclonal™ antibody.” The physical product and performance remain unchanged.

Target Information

Spectrins are principal components of the cell membrane-cytoskeleton, consisting of two alpha and two beta spectrin subunits. The SPTBN2 gene encodes spectrin beta non-erythrocytic 2 (beta-III spectrin), which regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.

Mutations in SPTBN2 cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.