Thermo Fisher Scientific S100A12 Polyclonal Antibody
S100A12 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C 보관, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | – |
| Neutralization (Neu) | – | 1 publication |
| Miscellaneous PubMed (Misc) | – | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human S100A12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720439 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
S100A12 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus of various cell types and are involved in regulating cellular processes such as cell cycle progression and differentiation.
S100A12 participates in calcium-dependent signal transduction pathways and regulates cytoskeletal components, influencing neutrophil activities. It acts as a ligand for RAGE, triggering activation in mononuclear phagocytes, lymphocytes, and endothelial cells. Activation of NF-κB by S100A12/RAGE plays a key role in inflammatory responses. S100A12 also exhibits antimicrobial properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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