Thermo Fisher Scientific Sorcin Polyclonal Antibody
Sorcin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 높은 순도(>95%)로 정제되어 연구용으로 적합. 인간, 생쥐, 랫트 반응성.
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Thermo Fisher Scientific Sorcin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human Sorcin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720741 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium-binding proteins and contains 4 EF-hand calcium-binding motifs.
Human Sorcin shares 95% sequence identity with hamster Sorcin. It associates with sarcolemmal proteins such as Annexin VII, cardiac ryanodine receptors, and L-type Ca²⁺ channels, influencing intracellular Ca²⁺ homeostasis.
It plays an important role in regulating intracellular Ca²⁺ cycling and Ca²⁺ influx pathways in heart and skeletal muscle during excitation-contraction.
Sorcin is overproduced in many multidrug resistance (MDR) cells and regulates apoptosis pathways, making it a potential MDR marker for prognosis of acute myeloid leukemia (AML) and a target for anti-MDR drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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