Thermo Fisher Scientific Phospho-Tau (Ser416) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000 dilution

Product Specifications

Product Specific Information

A suggested positive control for Western blot is rat brain, rat hippocampus, or mouse brain cells.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Axonal polarity is predetermined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome.
Short isoforms allow cytoskeletal plasticity; longer isoforms contribute to stabilization.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), a key component of neurofibrillary lesions in Alzheimer’s disease (AD).
Phosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration.
Kinases involved include GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is found in neurofibrillary lesions in AD and other CNS disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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