Thermo Fisher Scientific PRDX4 Monoclonal Antibody (1A1)

Thermo Fisher Scientific PRDX4 Monoclonal Antibody (1A1)

Applications and Tested Dilution

• Immunoprecipitation (IP): 1–2 µL

Product Specifications

Product Specific Information

A suggested positive control for this product is HeLa cells.

Target Information

Peroxiredoxin (Prx) is a growing peroxidase family involved in cell proliferation, differentiation, and apoptosis. Mammalian Prx proteins are categorized based on amino acid sequence homology and active site cysteine residues, exhibiting thiol-specific antioxidant activity.
There are six mammalian Prx members: typical 2-Cys, atypical 2-Cys, and 1-Cys Prx.

• Prx VI belongs to the 1-Cys Prx subgroup.
• The other five 2-Cys Prx isotypes have thioredoxin-dependent peroxidase (TPx) activity using thioredoxin, thioredoxin reductase, and NADPH as a reducing system.
  Mammalian Prxs (20–30 kDa) vary in subcellular localization:
• Prx I, II, VI: Cytosol
• Prx III: Mitochondria
• Prx IV: ER and secretion
• Prx V: Peroxisome, mitochondria, and cytosol

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.