Thermo Fisher Scientific Paxillin Polyclonal Antibody
Thermo Fisher Scientific의 Paxillin Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot과 ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, 액상 형태이며 고순도의 친화 크로마토그래피로 정제되었습니다. 세포 접착 및 신호전달 연구에 활용됩니다.
- 카탈로그번호
- PA5120618
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human Paxillin (NP_002850.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.09 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914190 |
Product Specific Information
- Positive test controls: PC-3
- Localization: Cell junction, Cytoplasm, Cell cortex, Cytoskeleton, Focal adhesion
Immunogen sequence:
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain, independently of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also play a role during neurite extension in differentiation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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