Thermo Fisher Scientific PML-5 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PML-5 protein. Validated for WB and ICC/IF applications. Recognizes regions within amino acids 300–600 of PML. Supplied as liquid, unconjugated form at 0.88 mg/mL. Suitable for research use in cellular localiz...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 300–600 of human PML (NP_1502412) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2914185 |
Product Specific Information
Positive test controls include:
- Rat spleen
- Rat lung
- Rat kidney
Localization of target:
- Cytoplasm
- Cytoplasmic side
- Early endosome membrane
- Endoplasmic reticulum membrane
- Nucleus
- PML body
- Peripheral membrane protein
- Nucleolus
- Nucleoplasm
Immunogen sequence:
AVDARYQRDY EEMASRLGRL DAVLQRIRTG SALVQRMKCY ASDQEVLDMH GFLRQALCRL RQEEPQSLQA AVRTDGFDEF KVRLQDLSSC ITQGKDAAVS KKASPEAAST PRDPIDVDLP EEAERVKAQV QALGLAEAQP MAVVQSVPGA HPVPVYAFSI KGPSYGEDVS NTTTAQKRKC SQTQCPRKVI KMESEEGKEA RLARSSPEQP RPSTSKAVSP PHLDGPPSPR SPVIGSEVFL PNSNHVASGA GEAEERVVVI SSSEDSDAEN SSSRELDDSS SESSDLQLEG PSTLRVLDEN L
Target Information
Functions via association with PML-nuclear bodies (PML-NBs) in key cellular processes such as:
- Tumor suppression
- Transcriptional regulation
- Apoptosis
- Senescence
- DNA damage response
- Viral defense mechanisms
Acts as the scaffold of PML-NBs allowing proteins to shuttle in and out, regulated by SUMO-mediated modifications and interactions. [Uniprot]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(PA5-120613_PML-5_P29590-1_Rabbit.svg 및 PA5-120613_PML-5_P29590-1_Rabbit_PDP.jpeg 이미지 포함)
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