Thermo Fisher Scientific FGFR substrate 3 Polyclonal Antibody
FGFR substrate 3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications 및 Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human FGFR substrate 3 (amino acids 401–492) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FRS3 (Fibroblast Growth Factor Receptor Substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein containing an IRS-type PTB domain. It colocalizes with neural tissues (Tuj1) and functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, acting as a potential tumor suppressor.
FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and serves as an adapter protein linking c-Fgr and NGF receptors to downstream signaling pathways. It interferes with phosphorylation and nuclear translocation of ERK-2, thereby down-regulating ERK-2 expression. FRS3 interacts with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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