Thermo Fisher Scientific Syntrophin-1+2+3 Polyclonal Antibody
인간, 마우스, 랫트 반응성의 Syntrophin-1+2+3 폴리클로날 항체로 다양한 면역학적 응용에 적합. Rabbit IgG 기반으로 Protein A 정제. 고농도(1 mg/mL) 액상 형태이며 -20°C 보관. 심근 및 신경근 접합부 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Syntrophin-1+2+3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. It associates cardiac sodium channels with the nitric oxide synthase-PMCA4b complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) and sudden infant death syndrome (SIDS). Syntrophins also associate with dystrophin and related proteins at the neuromuscular junction and influence intracellular calcium ion levels in muscle tissue.
[provided by RefSeq, Jan 2013]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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