Thermo Fisher Scientific CXCR4 (extracellular) Polyclonal Antibody, Atto 488

Applications

• Flow Cytometry (Flow): 5–10 µg / 5×10⁵ cells

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• The antibody ships as a lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

CXCR4 (also known as Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven transmembrane domains. It functions as a co-receptor for X4 HIV-1 entry into CD4⁺ cells and also mediates HIV-2 binding and fusion. CXCR4 serves as the receptor for the C-X-C chemokine CXCL12/SDF-1, triggering intracellular calcium increase and MAPK1/MAPK3 activation. It also acts as a receptor for extracellular ubiquitin, influencing intracellular calcium and cAMP levels. CXCR4 is involved in hematopoiesis, cardiac and vascular development, and neuronal survival. Antibodies to CXCR4 can block HIV-1 and HIV-2 fusion and infection of human target cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.