Thermo Fisher Scientific APOBEC3H Polyclonal Antibody
Human APOBEC3H 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합. 1 mg/mL 농도의 액상 형태이며, PBS 및 50% glycerol buffer에 보관. Affinity chromatography로 정제되어 높은 특이성과 안정성을 제공.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human APOBEC3H (Accession Q6NTF7), corresponding to amino acid residues N147–D197 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853120 |
Product Specific Information
Antibody detects endogenous levels of total APOBEC3H.
Target Information
DNA deaminase (cytidine deaminase) that inhibits retrovirus replication and retrotransposon mobility through deaminase-dependent and -independent mechanisms.
The A3H-var/haplotype 2 shows antiviral activity against vif-deficient HIV-1.
After retroviral nucleocapsid penetration and initiation of reverse transcription, it converts cytosine to uracil in minus-sense viral DNA, causing G-to-A hypermutations in plus-strand DNA.
This leads to detrimental levels of mutations and efficient antiretroviral effects.
It selectively targets single-stranded DNA and does not act on double-stranded DNA or RNA.
Also exhibits antiviral activity against HTLV-1 and may inhibit mobility of LTR and non-LTR retrotransposons.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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