Thermo Fisher Scientific DGAT2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
• View 2 publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500
• View references

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total DGAT2.

Target Information

Acyl-coenzyme A:diacylglycerol acyltransferase (DGAT), also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates.
DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation.
DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl₂ in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, suggesting an important role in mammalian triglyceride metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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