Thermo Fisher Scientific Phospho-CtIP (Ser327) Polyclonal Antibody
Human 및 Mouse 시료에서 CtIP 단백질의 Ser327 인산화를 검출하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도, PBS/glycerol buffer에 보관. 단백질 인산화 연구 및 DNA 손상 반응 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human CtIP around the phosphorylation site of Serine 327 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554014 |
Product Specific Information
- Detects endogenous CtIP protein at approximately 110 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
CtIP (CtBP-Interacting Protein) is a 125 kDa protein originally identified through its interaction with the transcriptional repressor CtBP via the PLDLS motif, suggesting a role in transcription regulation.
It also interacts with BRCA1 through the BRCT domains at the C-terminus, indicating potential tumor suppressor function.
The CtIP–BRCA1 interaction can be disrupted by DNA-damaging agents such as UV or gamma irradiation.
ATM kinase phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites prevents BRCA1 dissociation from CtIP, leading to sustained repression of BRCA1-dependent GADD45 induction after ionizing radiation (Li et al., Nature 406, 210–215, 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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