Thermo Fisher Scientific C5AR1 Monoclonal Antibody (S5/1), PE

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

10 µL/1x10^6 cells

-

Product Specifications

Species Reactivity

Bovine, Ferret, Human, Rabbit

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

S5/1

Immunogen

Human C5aR (Asp15-Asp27, N-terminal region) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C5AR1,uniProtId:P21730-1,ncbiNodeId:9606,antigenRange:15-27,antigenLength:350,antigenImageFileName:MA5-28535_C5AR1_P21730-1_House_mouse.svg,antigenImageFileNamePDP:MA5-28535_C5AR1_P21730-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745494

Product Specific Information

This antibody recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.

Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.

Target Information

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.