Thermo Fisher Scientific C5AR1 Monoclonal Antibody (S5/1), PE
PE 형광 표지된 C5AR1 단클론 항체로 인간, 소, 토끼, 페럿 시료에 반응. Flow Cytometry용으로 최적화된 제품이며, CD88 단백질의 세포외 에피토프를 인식. 4°C 암소 보관, 동결 금지.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Ferret, Human, Rabbit |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S5/1 |
| Immunogen | Human C5aR (Asp15–Asp27, N-terminal region) |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745494 |
Product Specific Information
This antibody recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of the C5a component of the complement cascade.
Recommended dilution is for 100 µL of whole blood or 1×10⁶ cells in suspension.
Target Information
CD88 (C5aR1) is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production.
It is a component of the classical pathway of the complement cascade and may be involved in tissue injury associated with ischemia or sepsis, as well as the membrane attack complex.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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