Thermo Fisher Scientific PCSK2 Polyclonal Antibody
Rabbit polyclonal antibody against human PCSK2 (Prohormone Convertase 2). Validated for WB, ICC/IF, and IP. Detects ~82 kDa band. Supplied as liquid, 1.36 mg/mL. For research use only.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PCSK2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide GLQDSSTDNRAKLC, corresponding to amino acids 95–107 of Human PC2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.36 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2134316 |
Product Specific Information
PA1-31853 has been successfully used in immunofluorescence and Western blot applications, where a band of approximately 82 kDa is detected.
Target Information
The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins transported by the constitutive secretory pathway are also targeted for maturation by PCs.
PC family members share structural similarities, including:
- A heterogeneous ~10 kDa amino-terminal proregion
- A highly conserved ~55 kDa subtilisin-like catalytic domain
- A carboxyl-terminal domain that is heterogeneous in length and sequence
These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment.
Immunolocalization studies show that PC1 is found in the perinuclear region and trans-Golgi network, whereas PC2 is found in the trans-Golgi network and diffusely distributed in the peripheral cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.