Thermo Fisher Scientific PrP Polyclonal Antibody
Thermo Fisher Scientific의 PrP Polyclonal Antibody는 인간 및 가축 프리온 단백질 검출용 연구 시약입니다. Western blot에 최적화되어 있으며, Rabbit IgG 폴리클로날 형식으로 제작되었습니다. 고순도 Protein G 정제 및 안정적인 PBS 기반 보존액을 사용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
- Suggested positive control: recombinant fusion protein
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Bovine, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 162–170 of BSE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1086794 |
Target Information
Human prion protein (PrP, also known as PRNP) is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functioning as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step triggering prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD).
PrPc is rich in alpha-helices, whereas PrPSc has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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