Thermo Fisher Scientific DEFB4 Monoclonal Antibody (4C4)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 3 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

Target Information

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.
The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds.
To date, six human beta-defensins have been identified: BD-1, BD-2, BD-3, BD-4, BD-5, and BD-6.
Beta-defensins are expressed on some leukocytes and at epithelial surfaces.
In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.
The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.
Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.