Thermo Fisher Scientific DFFA Monoclonal Antibody (3A11)
DFFA 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3A11). Western blot, ELISA, in situ PLA에 적합하며, 인간 시료 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
| in situ PLA | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A11 |
| Immunogen | DFFA (NP_004392.1, 231–331 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TSSDVALASH ILTALREKQA PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE RELALRLQQT QSLHSLRSIS ASKASPPGDL QNPKRARQDP T
Target Information
ICAD (Inhibitor of Caspase-3-Activated DNase) controls nuclear apoptosis by inhibiting CAD.
ICAD has two isoforms:
- ICAD-L/DFF45 (45 kDa) – functional isoform
- ICAD-S/DFF35 (35 kDa) – non-functional isoform
ICAD is cleaved by caspase-3 at residues 117 and 224, releasing CAD and initiating apoptotic DNA fragmentation.
In non-apoptotic cells, CAD is complexed with ICAD. ICAD also acts as a CAD-specific folding chaperone.
Recent studies suggest ICAD may be a potential target for restoring normal apoptotic signaling in colon and brain cancer cells.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified for the ICAD gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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