Thermo Fisher Scientific AFP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract, and the liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of AFP may also occur in individuals with no apparent pathology. The protein is considered the fetal counterpart of serum albumin, with AFP and albumin genes located tandemly on chromosome 4 in the same transcriptional orientation. AFP exists in monomeric, dimeric, and trimeric forms and can bind to copper ions, nickel ions, fatty acids, and bilirubin. AFP levels in amniotic fluid are used to assess renal protein loss and screen for spina bifida and anencephaly. Elevated serum AFP levels have been identified in hepatocellular carcinoma (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.