Thermo Fisher Scientific NUMBL Polyclonal Antibody
NUMBL 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간·마우스·랫에서 반응합니다. WB, IHC, ICC 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경발생 연구 및 NF-kappa-B 신호 조절 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 200–300 of Human NUMBL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982602 |
Product Specific Information
This antibody is predicted to react with cow and human based on sequence homology.
Target Information
NUMBL plays a role in neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells (radial glial cells) by allowing daughter cells to choose progenitor over neuronal cell fate. It is not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. NUMBL is also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblast survival and ependymal wall integrity.
It acts as a negative regulator of the NF-kappa-B signaling pathway by preventing MAP3K7IP2 from interacting with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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