Thermo Fisher Scientific PROX1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PROX1 protein. Validated for Western blot (1–2 µg/mL). Recognizes human, mouse, and rat. Purified via antigen affinity chromatography. Supplied as liquid, 1 mg/mL in PBS with BSA and sodium azide; store at 4°C...
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Applications
- Western Blot (WB): Tested dilution 1–2 µg/mL
Note: Non-specific bands observed at 25 kDa.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 150–250 of Human PROX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984353 |
Target Information
The expression pattern of the Prox1 homeobox gene suggests roles in various embryonic tissues, including the lens. Prox1 mRNA is present in many human tissues, with the highest level in the lens. Homozygous Prox1−/− mice die midgestation due to multiple developmental defects, including lens abnormalities. Prox1 inactivation leads to aberrant cellular proliferation, downregulation of Cdkn1b and Cdkn1c, misexpression of E-cadherin, and increased apoptosis, resulting in defective lens formation.
Prox1 is expressed in endothelial cells that form the lymphatic system, acting as a specific regulator of lymphatic development. It also regulates hepatocyte migration in mice; loss of Prox1 causes smaller livers with fewer clustered hepatocytes. In the embryonic retina, Prox1 controls progenitor cell cycle exit and differentiation, playing a key role in proliferation and fate determination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-19668_PROX1_Q92786-1_Rabbit.svg 및 PA5-19668_PROX1_Q92786-1_Rabbit_PDP.jpeg)
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