Thermo Fisher Scientific Calsequestrin 2 Polyclonal Antibody
Calsequestrin 2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P) 등 다양한 응용 가능. Human 및 Mouse 반응성, 항원 친화 크로마토그래피로 정제됨. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing a sequence corresponding to amino acids 124–388 (O14958) of Calsequestrin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.68 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_11152287 |
Product Specific Information
- Recommended positive control: HCT116
- Predicted reactivity: Mouse (95%), Rat (96%), Dog (96%), Rabbit (96%), Chicken (90%), Bovine (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Calsequestrin (CASQ) is a Ca²⁺-binding protein located primarily in the junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form (CASQ2) is encoded by a separate gene. CASQ2’s primary role is buffering sarcoplasmic reticulum Ca²⁺ ions, and it also regulates the open probability of ryanodine receptor 2 (RyR2).
Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia (CPVT2), characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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