Thermo Fisher Scientific 4E-BP2 Polyclonal Antibody
Human 4E-BP2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. 단백질 번역 개시 조절 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human 4E-BP2. Recombinant protein control fragment (Product #RP-103417). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637494 |
Product Specific Information
- Immunogen sequence: HQPSQSRAIP TRTVAISDAA QLPHDYCTTP
- Highest antigen sequence identity: Mouse – 97%, Rat – 97%
Target Information
PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highly expressed in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA both in vitro and in cells.
Phosphorylation at specific sites promotes dissociation of PHAS/eIF-4E complexes, allowing eIF-4E to bind to eIF-4G (p220), thereby increasing the formation of the eIF-4F complex and enhancing translation initiation.
Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway regulates PHAS-I and -II, suggesting that PHAS proteins mediate the effects of this pathway on protein synthesis and cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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