
Thermo Fisher Scientific MLH3 Polyclonal Antibody
Rabbit polyclonal antibody against human MLH3, validated for Western blot. Recognizes amino acids 1–322 of MLH3. Suitable for A549, HeLa, HepG2, HCT116 cells. Provides high specificity and sensitivity for DNA mismatch repair studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–322 of Human MLH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.54 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548594 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116
- Predicted reactivity: Mouse (89%), Rat (88%), Rhesus Monkey (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are involved in maintaining genomic integrity during DNA replication and meiotic recombination. The MLH3 protein forms a heterodimer with other MLH family members. Somatic mutations in this gene are frequently observed in tumors exhibiting microsatellite instability, and germline mutations are associated with hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, with two full-length variants confirmed.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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