Thermo Fisher Scientific Glutamine Synthetase/GLUL Recombinant Rabbit Monoclonal Antibody (GLUL/8996R)
Recombinant rabbit monoclonal antibody recognizing human Glutamine Synthetase (GLUL). Validated for IHC (Paraffin). Supplied as liquid, 200 µg/mL, purified by Protein A/G. Suitable for research on metabolic regulation and neurological studies.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | GLUL/8996R |
| Immunogen | Recombinant fragment (around aa 200–373) of human GLUL protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human brain, stomach, or thyroid
- Cellular Location: Cytoplasm; Mitochondrion
Target Information
Glutamine synthetase (GLUL) belongs to the glutamine synthetase family. It catalyzes ammonia incorporation in animals through glutamate dehydrogenase and glutamine synthase activity. Glutamate plays a central role in mammalian nitrogen flow, acting as both a nitrogen donor and acceptor. It is also crucial in regulating neurotransmitter glutamate metabolism.
The enzyme’s activity is tightly regulated, including through adenylylation. Decreased GS activity has been observed in the cerebral cortex of Alzheimer’s disease brains, particularly near senile plaques, and under glucose deprivation conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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