Thermo Fisher Scientific TIGIT Monoclonal Antibody (MBSA43), Alexa Fluor 488, eBioscience

Applications

Immunohistochemistry (IHC)

• Not tested

Flow Cytometry (Flow)

• Tested dilution: 5 µL (0.25 µg)/test
• Applications reported: Flow cytometric analysis of normal human peripheral blood cells
• A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL
• Recommended cell number: 10⁵–10⁸ cells/test

Product Specifications

Product Specific Information

The MBSA43 monoclonal antibody reacts with human TIGIT (T cell immunoreceptor with Ig and ITIM domains), also known as VSTM3 or WUCAM.
This 26 kDa protein belongs to the poliovirus receptor (PVR) family and is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4⁺ T cells, and CD8⁺ T cells, but not on B cells or naive CD4⁺ T cells.
TIGIT expression may be upregulated upon activation of naive CD4⁺ T cells. It interacts with PVR family members such as CD155 and mediates communication between NK/T cells and antigen-presenting cells, fibroblasts, or endothelial cells expressing PVR-like proteins.

• MBSA43 is reported to cross-react with Rhesus macaque.
• Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.

Target Information

TIGIT binds with high affinity to the poliovirus receptor (PVR), leading to increased IL-10 secretion, decreased IL-12B secretion, and suppression of T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

Additional Formats Available

• Alexa Fluor 647
• Alexa Fluor 660
• Alexa Fluor 700
• APC
• eFluor 450
• FITC
• Functional Grade
• NovaFluor Red 700
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Custom conjugation available upon request

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