Thermo Fisher Scientific Phospho-RSK2 (Thr577) Polyclonal Antibody
RSK2 단백질의 Thr577 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합하며 사람, 생쥐, 랫트 시료 반응성. 고순도 정제 및 안정한 PBS/glycerol 저장용액 제공. 연구용으로만 사용.
- 카탈로그번호
- PA5105587
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RPS6KA3 (Accession P51812), corresponding to amino acid residues around phosphorylated Thr577 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817015 |
Product Specific Information
Antibody detects endogenous levels of RSK2 only when phosphorylated at Thr577.
Target Information
RPS6KA3 (RSK2) is a serine/threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation.
RPS6KA3 contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway.
The activity of this protein has been implicated in controlling cell growth and differentiation.
Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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