Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI1B2), TrueMAB
USP7 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Flow cytometry에 적합. Human 시료 반응성. TrueMAB 형식으로 높은 특이성과 재현성을 제공. 연구용으로 p53 안정화 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
USP7 (also known as HAUSP) is a ubiquitin specific protease that removes ubiquitin from substrate proteins. This enzyme stabilizes its substrates by counteracting ubiquitination-mediated degradation. USP7 is known as a direct antagonist of Mdm2, an E3 ubiquitin ligase for the tumor suppressor p53. Under normal conditions, Mdm2 promotes degradation of p53, but USP7 can deubiquitinate and stabilize p53 in response to oncogenic stress, suggesting a tumor suppressor role. USP7 may also participate in an alternative pathway to protect cells from oncogenic insults, potentially independent of ARF-mediated mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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