Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI1F12), TrueMAB
USP7 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. p53 안정화 관련 연구 및 종양 억제 기전 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F12 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins. Ubiquitylation typically regulates protein stability and degradation; thus, HAUSP activity stabilizes its substrates. It acts as an antagonist of Mdm2, which ubiquitinates and degrades p53. By deubiquitinating p53, HAUSP protects it from degradation, suggesting a tumor suppressor role. HAUSP may also participate in oncogenic stabilization of p53 through Myc and E1A pathways, potentially offering an alternative mechanism for cellular protection against oncogenic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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