Thermo Fisher Scientific RPL7A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GRLVHRKTCT TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI AKLEKAKAKE LATKLG

Positive Samples: A-549, A-431, HeLa, U-87MG, Jurkat, MCF7, Mouse kidney, Mouse liver

Target Information

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to DNA response elements.
This gene is included in the surfeit gene cluster, a group of tightly linked genes that do not share sequence similarity. It is co-transcribed with U24, U36a, U36b, and U36c small nucleolar RNA genes, located in its introns.
The gene can rearrange with the trk proto-oncogene to form the chimeric oncogene trk-2h, encoding an oncoprotein with the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. Multiple processed pseudogenes are dispersed throughout the genome.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.