Thermo Fisher Scientific IL-22 Monoclonal Antibody (IL22JOP), Functional Grade, eBioscience
IL-22 단백질의 생물활성을 억제하는 기능성 등급 단클론 항체로, 인간 및 마우스 IL-22에 반응합니다. 다양한 면역학적 분석(Flow, ELISA, IHC, Neutralization 등)에 사용 가능하며, 높은 순도와 낮은 엔도톡신 수준을 보장합니다. 연구용으로 적합합니다.
- 카탈로그번호
- 16-7222-xxx (5개 옵션)
- 판매단위
- pk
카탈로그
5개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-22 Monoclonal Antibody (IL22JOP), Functional Grade, eBioscience
Applications and Publications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | - | View 24 publications |
| ELISA | - | View 2 publications |
| Neutralization (Neu) | Assay-Dependent | View 4 publications |
| Functional Assay | Assay-Dependent | View 6 publications |
| Inhibition Assays (IA) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rhesus monkey |
| Published Species | Human, Mouse, Non-human primate, Rhesus monkey |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL22JOP |
| Conjugate | Functional Grade |
| Available Formats | APC, PerCP-eFluor 710, Request custom conjugation |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866263 |
Product Specific Information
Description:
The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20 kDa member of the IL-10 cytokine family secreted mainly by Th17 cells, NK cells, and other T cells. IL-23 can induce higher IL-22 levels in Th17 cells compared to IL-6 or TGF-β, suggesting IL-22 secretion by fully differentiated Th17 cells in vivo. IL-22 plays a protective role against bacterial infections in lungs and gut. Elevated IL-22 production has been observed in asthma, ankylosing spondylitis, and rheumatoid arthritis patients.
IL22JOP is also reported to recognize rhesus IL-22.
Applications Reported:
Reacts with and inhibits the bioactivity of human and mouse IL-22.
Applications Tested:
The ND50 of IL22JOP, determined by inhibition of IL-10 induction in COLO205 cells by IL-22, is 10–40 ng/mL in the presence of 0.2 ng/mL recombinant human or mouse IL-22. Neutralization dose varies with assay method, cytokine concentration, and cell type.
Storage and Handling:
Use in a sterile environment.
Filtration:
0.2 µm post-manufacturing filtered.
Purity:
90%, as determined by SDS-PAGE.
Endotoxin Level:
<0.001 ng/µg antibody, as determined by LAL assay.
Aggregation:
<10%, as determined by HPLC.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and interferons). It is primarily produced by activated T cells and NK cells. The IL-22 gene is located on chromosome 12q and structurally related to IL-10.
IL-22 acts via the heterodimeric receptor complex IL-22R1 and IL-10R2, activating the JAK-STAT signaling pathway. A soluble receptor, IL-22BP, antagonizes IL-22 signaling. IL-22 mainly targets nonimmune cells such as epithelial cells, hepatocytes, and keratinocytes, influencing innate immunity, inflammation, and tissue repair. It is upregulated during chronic inflammation and plays a key role in host defense and wound healing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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