Thermo Fisher Scientific TGF beta-2 Polyclonal Antibody

Thermo Fisher Scientific TGF beta-2 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:3,000
Publications: -

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%).
• Positive Control: K562, THP-1.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transforming Growth Factor (TGF) betas mediate many cell-to-cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals: TGF beta 1, TGF beta 2, and TGF beta 3. Each is synthesized as a precursor protein that is cleaved to yield a 112 amino acid polypeptide remaining associated with the latent portion of the molecule.
TGF beta polypeptides are multifunctional, influencing cell proliferation, differentiation, and other functions across various cell types. Both transformed and nonneoplastic tissues release transforming growth factors, and nearly all mammalian cells possess a specific TGF receptor.
Generally, mesenchymal cells are stimulated by TGF beta, while epithelial and neuroectodermal cells are inhibited. TGF beta 1, TGF beta 2, and TGF beta 1.2 exhibit similar biological activity but differ in receptor binding. TGF beta 2 is produced by many cell types and found at high concentrations in porcine platelets and mammalian bone. Latent TGF beta 2 is the predominant isoform in body fluids such as amniotic fluid, breast milk, and ocular humors.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.