Thermo Fisher Scientific Cytokeratin 14/17 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:300

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human Cytokeratin 14/17 [aa 261-310]. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Cytokeratin 14/17,uniProtId:P02533-1,ncbiNodeId:9606,antigenRange:261-310,antigenLength:472,antigenImageFileName:PA5-68451_Cytokeratin_1417_P02533-1_Rabbit.svg,antigenImageFileNamePDP:PA5-68451_Cytokeratin_1417_P02533-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:Cytokeratin 14/17,uniProtId:Q04695-1,ncbiNodeId:9606,antigenRange:261-310,antigenLength:432,antigenImageFileName:PA5-68451_Cytokeratin_1417_Q04695-1_Rabbit.svg,antigenImageFileNamePDP:PA5-68451_Cytokeratin_1417_Q04695-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2688416

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.