Thermo Fisher Scientific Cytokeratin 14/17 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:10,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:300

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

Cytokeratins (CK) are intermediate filaments found in epithelial cells, both keratinizing (e.g., skin) and non-keratinizing (e.g., mesothelial cells). Although not typical markers for endothelial cells, cytokeratins are also detected in some microvascular endothelial cells.
At least 20 CKs with molecular weights of 40–70 kDa and isoelectric points of 5–8.05 can be identified via 2D gel electrophoresis.
CKs are divided into two classes:

• Type I: acidic polypeptides
• Type II: basic polypeptides

Each epithelial cell expresses at least one member of each class.
Monoclonal antibodies to cytokeratin proteins serve as useful markers for tumor identification and classification.
Keratin 14, belonging to the acidic subfamily and paired with keratin 5, distinguishes stratified epithelial cells from simple epithelial cells and aids in identifying squamous cell carcinomas. It is also considered a prognostic marker in breast carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-68451_Cytokeratin_1417_P02533-1_Rabbit.svg, PA5-68451_Cytokeratin_1417_Q04695-1_Rabbit.svg 등)