Thermo Fisher Scientific Cytokeratin 14/17 Polyclonal Antibody
인간, 생쥐, 랫트에 반응하는 Rabbit Polyclonal 항체로, Cytokeratin 14/17을 검출합니다. Western blot 및 IHC(Paraffin) 실험에 적합하며, 고순도 affinity chromatography로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- PA568451
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Cytokeratin 14/17 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:10,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:300
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Cytokeratin 14/17 (aa 261–310) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2688416 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Cytokeratins (CK) are intermediate filaments found in epithelial cells, both keratinizing (e.g., skin) and non-keratinizing (e.g., mesothelial cells). Although not typical markers for endothelial cells, cytokeratins are also detected in some microvascular endothelial cells.
At least 20 CKs with molecular weights of 40–70 kDa and isoelectric points of 5–8.05 can be identified via 2D gel electrophoresis.
CKs are divided into two classes:
- Type I: acidic polypeptides
- Type II: basic polypeptides
Each epithelial cell expresses at least one member of each class.
Monoclonal antibodies to cytokeratin proteins serve as useful markers for tumor identification and classification.
Keratin 14, belonging to the acidic subfamily and paired with keratin 5, distinguishes stratified epithelial cells from simple epithelial cells and aids in identifying squamous cell carcinomas. It is also considered a prognostic marker in breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-68451_Cytokeratin_1417_P02533-1_Rabbit.svg, PA5-68451_Cytokeratin_1417_Q04695-1_Rabbit.svg 등)
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