Thermo Fisher Scientific MET Monoclonal Antibody (OTI2B5), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MET (c-MET) is a receptor-like tyrosine kinase involved in various cellular processes. Dysregulation of MET has been associated with multiple human malignancies. Upon ligand activation, MET interacts with key signaling molecules including PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of pathways such as RAS–ERK, PI3K–AKT, and PLCγ–PKC.

MET is essential in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and adult processes (wound healing, organ regeneration, tissue remodeling). Aberrant MET activity is implicated in cancers such as gastric, renal, and breast cancer, making it a valuable target in cancer research and diagnostics.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.