Thermo Fisher Scientific EphB1 Polyclonal Antibody

Applications

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

A suggested positive control for this product is human brain lysate.

Target Information

EPHB1 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapse formation and maturation.
EphB1 and other EphB family members are type I membrane-spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine-rich subdomains in the ectodomain, and a single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain.
EphB family proteins bind ephrins of the B class, ligands that are also transmembrane-spanning proteins capable of transmitting signals. EphB1 is expressed predominantly in developing neural structures in embryos and in vascular epithelium of kidney and other tissues. Upon binding to alternatively oligomerized ephrin B1, EphB1 signals regulation of cell attachment and cell-cell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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