Thermo Fisher Scientific C17orf96 Polyclonal Antibody
Thermo Fisher Scientific의 C17orf96 폴리클로날 항체는 인간 단백질을 인식하며 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, PRC2/EED-EZH2 복합체 연구에 유용합니다. 연구용으로만 사용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human C17orf96 (Recombinant protein control fragment, Product #RP-106610) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2661948 |
Product Specific Information
- Immunogen sequence: ETLCPAPRLAV PASPRGSPCS PTPRKPCRGT QEFSPL
- Highest antigen sequence identity to orthologs: mouse 89%, rat 92%
Target Information
Elongin BC and Polycomb repressive complex 2-associated protein (EPOP), also known as C17ORF96, is a scaffold protein that bridges the PRC2/EED-EZH2 complex and elongin BC complex.
It fine-tunes transcriptional regulation of polycomb group (PcG) target genes in embryonic stem cells (ESCs).
C17ORF96 plays a key role in genomic regions with both active and repressive chromatin properties by maintaining low-level expression of PcG target genes.
It recruits the elongin BC complex to restrict excessive PRC2/EED-EZH2 activity and interacts with USP7 to promote deubiquitination of H2B at promoter sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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