Thermo Fisher Scientific NIK Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 330-662 of human MAP3K14 (NP_0039452) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NIK,uniProtId:Q99558-1,ncbiNodeId:9606,antigenRange:330-662,antigenLength:947,antigenImageFileName:PA5-88155_NIK_Q99558-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88155_NIK_Q99558-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804697

Product Specific Information

Immunogen sequence: KFSVEEYLVH ALQGSVSSGQ AHSLTSLAKT WAARGSRSRE PSPKTEDNEG VLLTEKLKPV DYEYREEVHW ATHQLRLGRG SFGEVHRMED KQTGFQCAVK KVRLEVFRAE ELMACAGLTS PRIVPLYGAV REGPWVNIFM ELLEGGSLGQ LVKEQGCLPE DRALYYLGQA LEGLEYLHSR RILHGDVKAD NVLLSSDGSH AALCDFGHAV CLQPDGLGKS LLTGDYIPGT ETHMAPEVVL GRSCDAKVDV WSSCCMMLHM LNGCHPWTQF FRGPLCLKIA SEPPPVREIP PSCAPLTAQA IQEGLRKEPI HRVSAAELGG KVNRALQQVG GLK

Positive Samples: Raji; Cellular Location: Cytoplasm

Target Information

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.