Thermo Fisher Scientific IKBKE Monoclonal Antibody (OTI5D4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IKBKE is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and its suppression induces cell death.
NF-κB is a key transcription factor mediating immune and inflammatory responses. It is normally bound to IκB proteins in the cytoplasm, which inhibit its activity.
Phosphorylation of IκB by the IKK complex (IKK-α, IKK-β, and IKK-γ) triggers NF-κB activation.
IKK epsilon (IKBKE) is essential for NF-κB activation induced by PMA and T-cell receptors, but not by TNF-α or IL-1.
IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS in various tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.