Thermo Fisher Scientific MLL1 Polyclonal Antibody
MLL1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. Human에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C 보관하며, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 720 and 780 of human myeloid/lymphoid or mixed-lineage leukemia 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
KMT2A is a histone methyltransferase essential for early development and hematopoiesis. It acts as the catalytic subunit of the MLL1/MLL complex, mediating methylation of Lys-4 on histone H3 (H3K4me) and acetylation of Lys-16 on histone H4 (H4K16ac). Within the complex, KMT2A specifically catalyzes H3K4me, marking chromatin for epigenetic transcriptional activation. It exhibits weak methyltransferase activity alone and requires other complex components for full activity. KMT2A is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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