Thermo Fisher Scientific Chk1 Polyclonal Antibody
Chk1 단백항체로 인간 시료에서 사용 가능하며 WB, IHC, ICC 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로 1 mg/mL 농도 유지. DNA 손상 반응 관련 연구용으로 적합하며, 장기 보관 시 -20°C에서 안정적.
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Thermo Fisher Scientific Chk1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 259–351 of CHK1 (Uniprot ID#O14757) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2551978 |
Product Specific Information
- Recommended positive controls: human Chk1-transfected 293T cells
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 acts as a key mediator in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress.
Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, while normal cells remain arrested in G1 phase.
Thus, CHK1 is a potential therapeutic target for cancer treatment, particularly in p53-deficient cancers.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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