Thermo Fisher Scientific APRIL Monoclonal Antibody (Sacha-1)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

Assay-dependent

-

Immunocytochemistry (ICC/IF)

5 µg/mL

-

Flow Cytometry (Flow)

1 µg/mL

-

Product Specifications

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

Sacha-1

Immunogen

Recombinant fusion protein of resideus 105-250 of human APRIL fused to residues 16-108 of human headless ACRP30 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:APRIL,uniProtId:O75888-1,ncbiNodeId:9606,antigenRange:105-108,antigenLength:250,antigenImageFileName:MA1-21169_APRIL_O75888-1_Rat.svg,antigenImageFileNamePDP:MA1-21169_APRIL_O75888-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_2206548

Product Specific Information

MA1-21169 detects APRIL in Human and Mouse samples.

Target Information

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.