Thermo Fisher Scientific Mono-Methyl-Histone H1.1 (Lys21) Polyclonal Antibody
Rabbit polyclonal antibody specific for mono-methylated Histone H1.1 (Lys21). Human reactive, validated for ICC/IF and ELISA. Supplied as liquid in PBS with 50% glycerol. Suitable for chromatin structure and epigenetic research.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | — |
| ELISA | Assay-dependent | — |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from Human Histone H1.1 protein (18–30 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.14 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2915002 |
Product Specific Information
Antibody tested in Indirect ELISA.
Target Information
Histones are basic nuclear proteins responsible for the nucleosome structure of chromosomal fibers in eukaryotes. Two molecules each of H2A, H2B, H3, and H4 form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units called nucleosomes.
The linker histone H1 interacts with linker DNA between nucleosomes and contributes to chromatin compaction into higher-order structures.
Histone H1.1 is encoded by an intronless, replication-dependent gene that lacks a polyA tail and instead contains a palindromic termination element. This gene is located within the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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